The 2025 Copa de la Reina de Fútbol Round of 16 is set to kick off between December 19 and December 21, 2025, bringing together Spain’s top-flight women’s clubs and the clubs that progressed through earlier rounds in a high-stakes knockout format.
With 48 teams starting the tournament and eight single-match showdowns in the Round of 16, this stage sets the scene for thrilling, winner-takes-all battles as favorites and underdogs collide under the bright lights.
Get ready for women’s drama, surprises, and fierce competition — in the Copa de la Reina, any day can see lower-division or underdog teams topple the giants.
The upcoming Copa de la Reina de Fútbol Round of 16 are the perfect stage for rising stars to make their mark and for established clubs to assert their dominance before the quarter-finals.
2025 Copa de la Reina de Fútbol Round of 16 Schedule and Venues
All eight Round of 16 matches will take place across three consecutive days, with the first legs beginning on December 19 and concluding on December 21, 2025:
| Date | Match | Venue | Time (UTC) |
|---|---|---|---|
| December 19 | CE Europa vs Athletic Club | Nou Sardenya, Gràcia, Barcelona | TBD |
| December 20 | RCD Espanyol vs Real Madrid | Sant Adrià de Besòs | 18:00 |
| December 20 | FC Badalona vs Granada CF | Palamós | 18:00 |
| December 20 | Sevilla vs Costa Adeje Tenerife | Seville | 11:00 |
| December 21 | Deportivo Alavés vs Barcelona | Ciudad Deportiva José Luis Compañón 3, Vitoria | 18:00 |
| December 21 | Alhama vs Atlético Madrid | Estadio José Kubala, Murcia | 18:00 |
| December 21 | Madrid CFF vs SD Eibar | Fuenlabrada | 18:00 |
| December 21 | RC Deportivo vs Real Sociedad | Abegondo | TBD |
Complete 2025 Copa de la Reina de Round of 16 Matchups News
All Round of 16 ties are single-match knockouts played at the home ground of the lower-division opponent in the earlier qualifying rounds, or in designated neutral or home venues as determined by the draw. Matches ending in regular 90-minute draws will proceed directly to extra time (30 minutes) and then penalty kicks if necessary, with no away goals advantage applied.
The eight Cup of the Queen knockout ties present contrasting narratives between established Liga F powerhouses and lower-division survivors, each seeking to advance to the quarter-finals.
Barcelona vs Alavés (Away at Vitoria)
FC Barcelona, the defending Copa de la Reina champions and current league leaders with 15 points from 6 matches, face Deportivo Alavés at Ciudad Deportiva José Luis Compañón in Vitoria. This is the most high-profile matchup of the round, as Barcelona seeks to continue their domestic dominance.
The Catalan giants have a commanding head-to-head record against Alavés, winning 19 of 23 matches with only one Alavés victory and three draws. Barcelona enters with superior squad depth, though Alavés has demonstrated solid defensive organization, allowing only 0.92 goals per 90 minutes in Liga F—among the best defensive records in the league.
Key Barcelona midfielder Gavi and goalkeeper Marc-André ter Stegen are unavailable due to injury, while Alavés have their full squad available for selection.
Real Madrid vs Espanyol (Away in Barcelona)
Real Madrid travel to Barcelona to face RCD Espanyol in a clash between Liga F’s third-place team and eighth-place side. Real Madrid dominated a recent LaLiga encounter against Espanyol with a 2-0 victory, though this 2025 Copa de la Reina de format presents a different challenge in a single-elimination format.
The tie will be played at Espanyol’s home ground, giving the Barcelona-based club the advantage of familiar surroundings.
Granada vs Badalona (Home for Badalona)
FC Levante LP Badalona hosts Granada CF in a matchup between two Liga F mid-table teams. Badalona finished 8th in the 2024-25 season and earned their place in the Round of 16, while Granada sits 11th in the current Liga F standings.
Recent head-to-head encounters show a competitive dynamic, with Badalona claiming a 2-0 victory in September 2025 and a 0-2 loss in February 2025.
Sevilla vs Tenerife (Home for Sevilla)
Sevilla FC hosts CD Costa Adeje Tenerife in a fixture between two established Liga F teams. Sevilla enters as the higher-ranked side (7th in Liga F) but faces a tough challenge from Tenerife, who sit 5th in the current standings with strong recent form.
Notably, Tenerife delivered a commanding 4-0 victory over Sevilla in their most recent Liga F encounter in September 2025, suggesting momentum is with the Canary Islands club heading into this Copa tie.
Athletic Club vs CE Europa (Home for Europa)
CE Europa hosts Athletic Club at Nou Sardenya in Gràcia, Barcelona, in an intriguing encounter between a Liga F top-eight team and a Primera Federación (second-tier) survivor.
Athletic Club, who wrapped up the 2024-25 Liga F season in 10th place, will be eager to reassert themselves against lower-tier opposition. CE Europa booked their spot by edging past DUX Logroño on penalties in the previous round, showcasing their grit in knockout play.
Atlético Madrid vs Alhama CF (Home for Alhama)
Alhama CF ElPozo hosts Club Atlético de Madrid at Estadio José Kubala in Murcia on artificial turf—a significant factor that could influence play. This matchup carries historical significance, as these teams met in the 2023 Copa de la Reina semi-finals when Atlético overwhelmed Alhama with a 4-0 victory en route to the final. Alhama emerged as champions of the Primera RFEF (second tier) in the 2024-25 season and will seek redemption on home soil.
In their most recent Liga F encounter on November 1, 2025, Atlético dominated Alhama 4-0, with Ane Etxezarreta Jensen scoring twice, demonstrating the quality gap between the clubs. However, the cup format and home advantage provide Alhama with a genuine opportunity for an upset.
Madrid CFF vs Eibar (Home for Madrid CFF)
Madrid CFF face SD Eibar in a Liga F matchup between teams ranked 6th and 12th respectively in the current standings. Madrid CFF have the superior head-to-head record, winning their most recent Liga F encounter 1-0 in September 2025, and maintaining a strong overall record against Eibar. The Madrid-based club are favorites in this encounter.
Real Sociedad vs Deportivo La Coruña (Away for La Coruña)
RC Deportivo de la Coruña travel to face Real Sociedad de Fútbol at Real Sociedad’s home ground. Real Sociedad are ranked 2nd in Liga F with 14 points from 7 matches, making them strong favorites in this tie. Deportivo earned its Round of 16 place by advancing through the earlier qualifying rounds.
Real Sociedad won their most recent Copa de la Reina encounter against Deportivo 1-0 in December 2024, and holds a strong historical advantage with records showing dominance in head-to-head matchups.
Liga F Context
The 2025-26 Liga F season remains highly competitive, with FC Barcelona (25 points, 13 matches) leading the standings ahead of Real Sociedad (25 points) and Real Madrid (25 points).
The race for the title is exceptionally tight, with only three points separating first and fifth place, indicating a genuinely competitive season. Atlético de Madrid sits 4th with 24 points, while Costa Adeje Tenerife occupies 5th place with 23 points.